Meet Lucy,* a mNSCLC patient with a non-resistant EGFR mutation
- 39 years old
- Diagnosed with stage IV adenocarcinoma
- Biomarker test revealed a G719X mutation
- Started GILOTRIF first-line
*Not an actual patient
EGFR=epidermal growth factor receptor
Proven efficacy in non-resistant EGFR mutations1
- Among the 75 GILOTRIF-treated patients with uncommon EGFR mutations, 32 patients had a non-resistant EGFR mutation1
- The confirmed overall response rate, as assessed by independent radiology review, was 66% (95% CI, 47%-81%)1,15
- At the time of the assessment, among the 21 responders, 52% of patients had a response duration of ≥12 months and 33% had a response duration of ≥18 months1,15
Additional efficacy data by mutation1,9
Data are n (%, 95% CI) or median (95% CI). NE=not evaluable.
Consider GILOTRIF for your patients like Lucy with non-resistant mutations
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References: 1. GILOTRIF [prescribing information]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc. 2. Hochmair MJ, Morabito A, Hao D, et al. Sequential treatment with afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer: an observational study [published online October 19, 2018]. Future Oncol. doi:10.2217/fon-2018-0711 3. Halmos B, Tan EH, Soo Ra, et al. Impact of afatinib dose modification on safety and effectiveness in patients with EGFR mutation-positive advanced NSCLC: results from a global real-world study (RealGido). Lung Cancer. 2019;127:103-11. 4. Yang JCH, Wu YL, Schuler M, et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. Lancet Oncol. 2015;16(2):141-151. 5. Sequist LV, Yang JC, Yamamoto N, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol. 2013;31(27):3327-3334. 6. Ke EE, Zhou Q, Zhang QY, et al. A higher proportion of the EGFR T790M mutation may contribute to the better survival of patients with exon 19 deletions compared with those with L858R. J Thorac Oncol. 2017;12(9):1368-1375. 7. Data on file. Boehringer Ingelheim. CTR. 8. Lee CK, Wu YL, Ding PN, et al. Impact of specific epidermal growth factor receptor (EGFR) mutations and clinical characteristics on outcomes after treatment with EGFR tyrosine kinase inhibitors versus chemotherapy in EGFR-mutant lung cancer: a meta-analysis. J Clin Oncol. 2015;33(17):1958-1965. 9. Yang JC, Sequist LV, Geater SL, et al. Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX- Lung 2, LUX-Lung 3, and LUX-Lung 6. Lancet Oncol. 2015;16(7):830-838. 10. Yang JCH, Wu JYS, Hsia TC, et al. Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial. Lancet Oncol. 2012;13:539-548. 11. Wu YL, Zhou C, Hu CP, et al. Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial. Lancet Oncol. 2014;15(2):213-222. 12. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: non-small cell lung cancer, version 5. 2018. 13. Soria JC, Felip E, Cobo M, et al. Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung (LUX-Lung 8): an open-label randomised controlled phase 3 trial. Lancet Oncol. 2015;16(8):897 907. 14. Yang JCH, Sequist LV, Zhou C, et al. Effect of dose adjustment on the safety and efficacy of afatinib for EGFR mutation-positive lung adenocarcinoma: post hoc analyses of the randomized LUX-Lung 3 and 6 trials. Ann Oncol. 2016;27(11):2103-2110. 15. U.S. Food & Drug Administration (FDA). FDA broadens afatinib indication to previously untreated, metastatic NSCLC with other non-resistant EGFR mutations (press release). https://www.fda.gov/drugs/informationondrugs/approveddrugs/ucm592558.htm. Accessed 3.13.2019.
Indications and usage
- GILOTRIF (afatinib) tablets is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have non-resistant epidermal growth factor receptor (EGFR) mutations as detected by an FDA-approved test.
Limitation of Use: Safety and efficacy of GILOTRIF have not been established in patients whose tumors have resistant EGFR mutations.
- GILOTRIF is indicated for the treatment of patients with metastatic squamous NSCLC progressing after platinum-based chemotherapy.
ARs REPORTED IN LUX-Lung 3 IN ≥10% OF GILOTRIF-TREATED PATIENTS1
Other clinically important ARs observed in patients treated with GILOTRIF include decreased appetite (29%), nausea (25%), and vomiting (23%)1
*None of the ARs in this table except stomatitis (1 patient on GILOTRIF [0.4%]) were grade 4 in severity.
†Includes stomatitis, aphthous stomatitis, mucosal inflammation, mouth ulceration, oral mucosa erosion, mucosal erosion, mucosal ulceration.
‡Includes acne, acne pustular, dermatitis, acneiform dermatitis, dermatosis, drug eruption, erythema, exfoliative rash, folliculitis, rash, rash erythematous, rash follicular, rash generalized, rash macular, rash maculo-papular, rash pruritic, rash pustular, skin disorder, skin erosion, skin exfoliation, skin fissures, skin lesion, skin reaction, skin toxicity, skin ulcer.
§Includes paronychia, nail infection, nail bed infection.
LUX-Lung 2: SINGLE-ARM, MULTICENTER TRIAL10
- Single-arm study exploring the anti-tumor efficacy of GILOTRIF in EGFR M+ NSCLC patients with stage IIIB/IV disease
- Patients were treated with GILOTRIF 50 mg orally once daily (n=99) or 40 mg orally once daily (n=30)
- Primary endpoint was the proportion of patients with a confirmed objective response, as determined by RECIST 1.0 based on an independent review of imaging
LUX-Lung 3: GLOBAL TRIAL IN 345 PATIENTS WITH EGFR M+ mNSCLC5
- Randomized, multicenter, open-label trial that assessed the safety and efficacy of GILOTRIF 40 mg orally once daily (n=230) vs up to 6 cycles of pemetrexed-cisplatin (n=115) as first-line therapy in patients with EGFR M+ mNSCLC1,5
- Primary endpoint was PFS; key secondary endpoint was OS1,5
- Majority of patients had del19 or L858R mutations1,5
– 49% had del19, 40% had L858R, and 11% had uncommon mutations
LUX-Lung 6: A LARGE TRIAL IN ASIAN EGFR M+ NSCLC PATIENTS11
- Randomized, multinational, prospective, phase III trial that assessed the safety and efficacy of GILOTRIF 40 mg orally once daily (n=242) vs up to 6 cycles of gemcitabine-cisplatin (n=122) as first-line therapy in patients with EGFR M+ mNSCLC
- Primary endpoint was PFS
- Majority of patients had del19 or L858R mutations
– 51% had del19, 38% had L858R, and 11% had uncommon mutations